Google shows some previous work on S-nitrosation and Alzheimer's. But apparently not yet any promising research towards reversing damage in humans.A new study on Alzheimer's disease has revealed a previously unknown biochemical cascade in the brain that leads to the destruction of synapses, the connections between nerve cells that are responsible for memory and cognition.
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This newly-discovered series of abnormal chemical events, termed "protein transnitrosylation reactions," contribute to synapse loss, the main driver of memory loss and cognitive decline in Alzheimer's
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"We were able to show that these reactions occur in brains of Alzheimer's patients, and when we prevented these reactions in the brains of animal models of the disease, we protected the synapses," Lipton says. "Our findings suggest that it may be possible to intercede to reverse synapse damage in spite of plaques and tangles,"
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"With this new knowledge, we may be able to restore synaptic connections in Alzheimer's patients after extensive plaques and tangles have formed in their brains,"
The paywalled paper is: https://science.sciencemag.org/content/ ... ce.aaw0843
Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer’s disease
By Tomohiro Nakamura, Chang-ki Oh, Lujian Liao, Xu Zhang, Kevin M. Lopez, Daniel Gibbs, Amanda K. Deal, Henry R. Scott, Brian Spencer, Eliezer Masliah, Robert A. Rissman, John R. Yates III, Stuart A. Lipton
Science, 03 Dec 2020
DOI: 10.1126/science.aaw0843
